Cardiolipin and mitochondrial cristae organization
نویسندگان
چکیده
منابع مشابه
Bid-cardiolipin interaction at mitochondrial contact site contributes to mitochondrial cristae reorganization and cytochrome C release.
Release of cytochrome c from the mitochondrial intermembrane space is critical to apoptosis induced by a variety of death stimuli. Bid is a BH3-only prodeath Bcl-2 family protein that can potently activate this efflux. In the current study, we investigated the mitochondrial localization of Bid and its interactions with mitochondrial phospholipids, focusing on their relationships with Bid-induce...
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The inner membrane of mitochondria is especially protein rich and displays a unique morphology characterized by large invaginations, the mitochondrial cristae, and the inner boundary membrane, which is in proximity to the outer membrane. Mitochondrial inner membrane proteins appear to be not evenly distributed in the inner membrane, but instead organize into functionally distinct subcompartment...
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MATERIALS AND METHODS Stock cultures of T. aceti were grown axenically at 27 °C in a liquid medium described by Castillo and Krusberg (2) . Female nematodes from two cultures were examined, one of which had been maintained at East Wareham for 4 yr and the other obtained from the Department of Cell Physiology, Boston Biomedical Research Institute . Age at sacrifice for electron microscopy was de...
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< a d d a r t t y p e = " r e l " d o i = " 1 0. 1 0 8 3 / j c b. 2 0 1 5 0 8 0 9 9 " > Otera et al.< / a d d a r t > reveal that the mito-chondrial fi ssion factor Drp1 and its receptors MiD49 and MiD51 promote apoptosis by remodeling mitochondrial cristae. Early in apoptosis, mitochon-drial cristae are remodeled so that cytochrome c enters the space between the inner and outer mito-chondrial ...
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Because of the diffraction resolution barrier, optical microscopes have so far failed in visualizing the mitochondrial cristae, that is, the folds of the inner membrane of this 200 to 400 nm diameter sized tubular organelle. Realizing a approximately 30 nm isotropic subdiffraction resolution in isoSTED fluorescence nanoscopy, we have visualized these essential structures in the mitochondria of ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2017
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2017.03.013